PI: Rick Dijkhuizen, PhD
I am professor of Experimental and Translational Neuroimaging, and head of the Biomedical MR Imaging and Spectroscopy group, which is part of the Center for Image Sciences at the University Medical Center Utrecht (The Netherlands). My research focuses on multiparametric imaging of brain structure and function in health and disease, with particular emphasis on i) development of tools for improved diagnosis of brain pathophysiology, ii) characterization of neural network (re)organization, and iii) monitoring of neuroprotective and -restorative therapies.
Over the years, I have been involved in numerous studies that have demonstrated the potential of MRI methods for characterization of brain development, injury and plasticity. Currently, an important scientific aim within my research group is the elucidation of the (re)organization of brain networks and neurovasculature, particularly in relation to functional recovery after cerebrovascular injury in patients and animal models. This includes multimodal imaging approaches to understand the underlying (cellular and hemodynamic) mechanisms of normal and abnormal signaling in neural circuits. Insights from these studies should lead to development and implementation of diagnostic tools and therapeutic strategies that can improve outcome in patients with brain disorders.
I collaborate with various national and international institutions on topics such as stroke recovery, brain repair and functional imaging. In addition to my position at the UMC Utrecht, I am Associate Editor of Frontiers in Neurology/Stroke and the Journal of Cerebral Blood Flow and Metabolism.
Annette van der Toorn, PhD
I am presently working as MR physicist in the Dijkhuizen lab, where I help and train researchers to set up and execute MR studies, involving instructions and implementations of protocols. In addition I provide assistance when more elaborate post-processing is necessary. My personal projects mainly involve the development of fast (EPI) sequences for specific purposes, DKI/DTI imaging, and high-resolution post-mortem brain scanning.
I have been working at the Dijkhuizen lab since 2002. I got involved in and hooked on in vivo MR research after spending half a year at NIH in Bethesda, as part of my Master’s study (Molecular Sciences) at Wageningen University, which I finished in 1990. From 1990 until 1994, I did my PhD research in the current lab in Utrecht under Dr. Klaas Nicolay’s supervision, working on a 4.7 T scanner, which was the first scanner in the lab. This research involved localized spectroscopy after experimental stroke in cats and rats. From 1994 until 2002, I was a post-doc at Wageningen University and at the University in Würzburg, performing MR experiments to study flow and development in plants (1994-1999), and at the Biophysics department of Maastricht University, working on the quantification of myocardial MR tagging images to obtain information on cardiac function (1999-2002).
Jord Vink, PhD
My fascination with the workings of the human body started in high school. During the course of my undergrad, this fascination was drawn toward the human brain, specifically. Today, as a PhD student, I study the (electro)physiology of the brain in healthy individuals and patients with brain damage (i.e. stroke, epilepsy and oncology) as part of various projects and collaborations. Besides my research, I also work at a startup company. This work provides me with a different perspective on neuroscience, sparking new ideas for my research.